The inaugural Sensor Interfaces Meeting (IEEE SIM’22), sponsored by the IEEE Sensors Council, took place on May 16–17, 2022, at ASML in Veldhoven, the Netherlands. IEEE SIM’22 was a focused, high-quality workshop addressing the state of the art, challenges, and future trends in sensor interface electronics. The two-day event featured invited talks from leading experts in industry and academia, opportunities for interaction and discussion, and an integrated exhibits program showcasing developments in sensors and sensor systems.